Journal
NATURE GENETICS
Volume 41, Issue 10, Pages 1058-1060Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.452
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Funding
- Cancer Research UK [C5047/A7357, 10588, 11022, C16913/A6835, C1287/A10118, C16913/A6135, C5047/A10692, 10118, C5047/A3354] Funding Source: Medline
- Medical Research Council [G0500966, G0501019] Funding Source: Medline
- Department of Health Funding Source: Medline
- MRC [G0500966, G0501019] Funding Source: UKRI
- Cancer Research UK [10588, 10118, 11022] Funding Source: researchfish
- Medical Research Council [G0501019, G0500966] Funding Source: researchfish
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Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.
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