Journal
NATURE GENETICS
Volume 41, Issue 7, Pages 854-U121Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.376
Keywords
-
Categories
Funding
- US National Institutes of Health [NS050223]
- National Multiple Sclerosis Society [RG 3943-A-2]
- Muscular Dystrophy Association [MDA4061]
- Biotechnology and Biological Sciences Research Council, UK
- Biotechnology and Biological Sciences Research Council [BB/F023243/1] Funding Source: researchfish
- BBSRC [BB/F023243/1] Funding Source: UKRI
Ask authors/readers for more resources
The kinesin motor protein Kif1b has previously been implicated in the axonal transport of mitochondria and synaptic vesicles(1,2). More recently, KIF1B has been associated with susceptibility to multiple sclerosis (MS)(3). Here we show that Kif1b is required for the localization of mbp (myelin basic protein) mRNA to processes of myelinating oligodendrocytes in zebrafish. We observe the ectopic appearance of myelin-like membrane in kif1b mutants, coincident with the ectopic localization of myelin proteins in kif1b mutant oligodendrocyte cell bodies. These observations suggest that oligodendrocytes localize certain mRNA molecules, namely those encoding small basic proteins such as MBP, to prevent aberrant effects of these proteins elsewhere in the cell. We also find that Kif1b is required for outgrowth of some of the longest axons in the peripheral and central nervous systems. Our data demonstrate previously unknown functions of kif1b in vivo and provide insights into its possible roles in MS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available