Journal
NATURE GENETICS
Volume 41, Issue 5, Pages 609-613Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.355
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Funding
- L'Oreal-UNESCO for women in Science''
- Spanish Ministerio de Ciencia y Tecnologia
- Spanish Ministerio de Ciencia y Tecnologia [SAF2005-06355]
- Spanish Fondo de Investigaciones anitarias [FIS CP03/00014, PI08/0045, PI-051942, G03/203]
- European Commission [LSHG-CT-2006-037900, LSHG-CT-2004-512063]
- Deafness Research UK
- Wellcome Trust
- MRC [G0300212, MC_qA137918] Funding Source: UKRI
- Medical Research Council [MC_qA137918, G0300212] Funding Source: researchfish
- RNID [G41] Funding Source: researchfish
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MicroRNAs (miRNAs) bind to complementary sites in their target mRNAs to mediate post-transcriptional repression(1,2), with the specificity of target recognition being crucially dependent on the miRNA seed region(3). Impaired miRNA target binding resulting from SNPs within mRNA target sites has been shown to lead to pathologies associated with dysregulated gene expression(4-7). However, no pathogenic mutations within the mature sequence of a miRNA have been reported so far. Here we show that point mutations in the seed region of miR-96, a miRNA expressed in hair cells of the inner ear(8), result in autosomal dominant, progressive hearing loss. This is the first study implicating a miRNA in a mendelian disorder. The identified mutations have a strong impact on miR-96 biogenesis and result in a significant reduction of mRNA targeting. We propose that these mutations alter the regulatory role of miR-96 in maintaining gene expression profiles in hair cells required for their normal function.
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