Journal
NATURE GENETICS
Volume 41, Issue 2, Pages 216-220Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.275
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Funding
- NIDDK IBD Genetics Consortium [DK062431, DK062422, DK062420, DK062432, DK062423, DK062413, DK062429]
- Atran Foundation
- Board of Governor's Chair in Medical Genetics at Cedars-Sinai Medical Center
- Bohmfalk Funds for Medical Research
- Burroughs Wellcome Medical Foundation
- Crohn's and Colitis Foundation of America
- Crohn's and Colitis Foundation of Canada
- Feintech Chair in Immunobiology
- Gale and Graham Wright Research Chair in Digestive Diseases
- Harvey M. and Lyn P. Meyerhoff Inflammatory Bowel Disease Center
- US National Institutes of Health [RR00052, DK077905, DK068112, DK072373, RR024139, DK076025, DK064869, MH057881, DK046763, RR00425]
- Rainin IBD Genetics Research Fund
- W. Buford Lewis family
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Ulcerative colitis is a chronic inflammatory disease of the colon that presents as diarrhea and gastrointestinal bleeding. We performed a genome-wide association study using DNA samples from 1,052 individuals with ulcerative colitis and preexisting data from 2,571 controls, all of European ancestry. In an analysis that controlled for gender and population structure, ulcerative colitis loci attaining genome-wide significance and subsequent replication in two independent populations were identified on chromosomes 1p36 (rs6426833, combined P = 5.1 x 10(-13), combined odds ratio OR = 0.73) and 12q15 (rs1558744, combined P = 2.5 x 10(-12), combined OR = 1.35). In addition, combined genome-wide significant evidence for association was found in a region spanning BTNL2 to HLA-DQB1 on chromosome 6p21 (rs2395185, combined P = 1.0 x 10(-16), combined OR = 0.66) and at the IL23R locus on chromosome 1p31 (rs11209026, combined P = 1.3 x 10(-8), combined OR = 0.56; rs10889677, combined P = 1.3 x 10(-8), combined OR = 1.29).
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