Journal
NATURE GENETICS
Volume 41, Issue 8, Pages 873-875Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.419
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Funding
- US National Institutes of Health [CA122663, CA104862, CA45614, CA89745, CA87014, HL086528]
- American Cancer Society [IRG-07-06401]
- Stardust Foundation
- Canadian Cancer Society and National Cancer Institute of Canada
- Canadian Institutes of Health Research
- German Jose Carreras Leukemia Foundation [DJCLS R04/08, R07/26]
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We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1).
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