Journal
NATURE GENETICS
Volume 41, Issue 11, Pages 1164-1166Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng1109-1164
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Epigenetic marks, such as DNA methylation and histone modifications, undergo dynamic changes during cellular differentiation and development. A new study demonstrates that DNA methylation by Dnmt1 protects essential stem cell properties in both hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs) by silencing differentiation programs that interfere with self-renewal and multipotency.
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