Journal
NATURE GENETICS
Volume 41, Issue 1, Pages 25-34Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.287
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Funding
- NATIONAL CANCER INSTITUTE [P01CA087969, R01CA049449, U01CA049449, R01CA050385, R01CA067262, R01CA065725, U01CA067262, U01CA098233] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL087679, U01HL084729] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [Z01HG000024, N01HG065403, ZIAHG000024, R01HG002651] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R56DK062370, R01DK062370, F32DK079466, R01DK029867, K23DK080145, K23DK067288, U01DK062370, T32DK007191, R01DK075787, R01DK072193] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [RL1MH083268] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [ZIAAG000675, ZIAAG000799, ZIAAG001050] Funding Source: NIH RePORTER
- Medical Research Council [U1475000001] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10082] Funding Source: researchfish
- MRC [G0800582, G9824984, MC_U147585827, G9521010, MC_U106188470, G0400491, G0400874, MC_U105630924, G0000934, G0701863, G0601261, G0600705, MC_U106179472, MC_U147585819] Funding Source: UKRI
- British Heart Foundation [FS/05/061/19501] Funding Source: Medline
- Intramural NIH HHS [Z01 HG000024] Funding Source: Medline
- Medical Research Council [U.1475.00.003.00010.02 (85819), G0600705, G0401527, MC_U105630924, MC_UP_A620_1014, G0400491, MC_U106179472, G9521010, G9824984, G0701863, G0400874, G0800582, G9815508, G0000934, MC_U147585827, MC_U106179471, MC_U106188470, MC_U147585824, G0601261, MC_U147585819, G0000649] Funding Source: Medline
- NCI NIH HHS [CA65725, CA87969, R01 CA049449, R01 CA067262, 5UO1CA098233, U01 CA049449, R01 CA065725, P01 CA087969, CA49449, R01 CA050385, U01 CA098233, U01 CA067262, CA50385, CA67262] Funding Source: Medline
- NHGRI NIH HHS [1Z01 HG000024, 01-HG-65403, N01HG65403, HG02651, R01 HG002651] Funding Source: Medline
- NHLBI NIH HHS [U01 HL084729, HL084729, HL087679, R01 HL087679] Funding Source: Medline
- NIA NIH HHS [N01-AG-1-2109] Funding Source: Medline
- NIDDK NIH HHS [DK072193, F32 DK079466-01, R01 DK029867, T32DK07191, U01 DK062370, DK062370, R56 DK062370, DK075787, R01 DK072193, K23 DK080145, K23 DK080145-01, F32 DK079466, R01 DK075787, T32 DK007191, R01 DK062370, K23 DK067288] Funding Source: Medline
- NIMH NIH HHS [1RL1MH083268, RL1 MH083268] Funding Source: Medline
- Wellcome Trust [077016, 089061, 079557, 082390, 090532, 068545/Z/02, 076113, 077011, 076467/Z/05/Z] Funding Source: Medline
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Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
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