Journal
NATURE GENETICS
Volume 40, Issue 6, Pages 703-706Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.131
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Funding
- NATIONAL CANCER INSTITUTE [R01CA089085] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA89085-01A] Funding Source: Medline
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We carried out a genome-wide association study of breast cancer predisposition with replication and refinement studies involving 6,145 cases and 33,016 controls and identified two SNPs (rs4415084 and rs10941679) on 5p12 that confer risk, preferentially for estrogen receptor (ER)-positive tumors (OR = 1.27, P = 2.5 x 10(-12) for rs10941679). The nearest gene, MRPS30, was previously implicated in apoptosis, ER-positive tumors and favorable prognosis. A recently reported signal in FGFR2 was also found to associate specifically with ER-positive breast cancer.
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