4.8 Article

Common sequence variants on 20q11.22 confer melanoma susceptibility

Journal

NATURE GENETICS
Volume 40, Issue 7, Pages 838-840

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/ng.163

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Funding

  1. NCI NIH HHS [R01 CA088363, CA083115, R01 CA083115, CA83115, R01 CA088363-07, R01 CA083115-08, CA109544, R01 CA109544, CA88363] Funding Source: Medline
  2. NHLBI NIH HHS [HL086528, U01 HL086528] Funding Source: Medline

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We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.

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