Journal
NATURE GENETICS
Volume 40, Issue 12, Pages 1404-1406Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.254
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Funding
- Institut National du Cancer, France
- European Community [LSHG-CT-2005-512113, MTKD-CT-2004-510114]
- Norwegian Cancer Association
- Research Council of Norway
- Ontario Institute of Cancer Research
- US National Cancer Institute [R01 CA092039]
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We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P - 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the independent study series (P = 7 x 10(-5) and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.
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