Journal
NATURE GENETICS
Volume 40, Issue 9, Pages 1062-1064Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.202
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Funding
- ABCoN contract [NO1-AR-1-2256]
- Mary Kirkland Center for Lupus Research
- Rainin Foundation
- National Center for Research Resources [5 M01 RR-00079]
- US Public Health Service
- [R01 AR44804]
- [K24 AR02175]
- [AI95386]
- [AR050267]
- [T32 DK07007]
- [U19 AI063603]
- [2R01 AR4658805]
- [K24 AR02213]
- [R01 HL 54900]
- [R01 HL 74165]
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The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-kappa B-dependent signaling and prevents inflammation. We show that three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) are associated with systemic lupus erythematosus (SLE) among individuals of European ancestry. These findings provide critical links between A20 and the etiology of SLE.
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