Journal
NATURE GENETICS
Volume 40, Issue 5, Pages 516-522Publisher
NATURE RESEARCH
DOI: 10.1038/ng.147
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Funding
- Medical Research Council [MC_U120061454] Funding Source: researchfish
- MRC [MC_U120061454] Funding Source: UKRI
- Medical Research Council [MC_U120061454] Funding Source: Medline
- NCI NIH HHS [R01 CA077876] Funding Source: Medline
- NIDDK NIH HHS [R01 DK059597] Funding Source: Medline
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The rat is an important system for modeling human disease. Four years ago, the rich 150-year history of rat research was transformed by the sequencing of the rat genome, ushering in an era of exceptional opportunity for identifying genes and pathways underlying disease phenotypes. Genome-wide association studies in human populations have recently provided a direct approach for finding robust genetic associations in common diseases, but identifying the precise genes and their mechanisms of action remains problematic. In the context of significant progress in rat genomic resources over the past decade, we outline achievements in rat gene discovery to date, show how these findings have been translated to human disease, and document an increasing pace of discovery of new disease genes, pathways and mechanisms. Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research.
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