Journal
SINGAPORE MEDICAL JOURNAL
Volume 56, Issue 1, Pages 7-10Publisher
SINGAPORE MEDICAL ASSOC
DOI: 10.11622/smedj.2015003
Keywords
biomarkers; creatinine; glomerular filtration rate; renal failure; urine
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Acute kidney injury (AKI) and chronic kidney disease (CKD) are major health problems. Urinary biomarkers have both diagnostic and prognostic utility in AKI and CKD. However, how biomarker excretion rates should be reported, especially whether they should be normalised to urinary creatinine concentration (uCr), is controversial. Some studies suggest that normalisation to uCr may be inappropriate at times, as urinary creatinine excretion rate may vary greatly, depending on the situation. Notably, recent studies suggest that while normalisation of values to UCr may be valid for the evaluation of CKD and prediction of AKI sequelae and occurrences, it could be inappropriate for the diagnosis of AKI, or in the presence of certain acute kidney disease states.
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