Journal
NATURE GENETICS
Volume 40, Issue 2, Pages 198-203Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.74
Keywords
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Categories
Funding
- MRC [G0000934, G0600705] Funding Source: UKRI
- Medical Research Council [G0600705, G0000934] Funding Source: researchfish
- Division Of Environmental Biology
- Direct For Biological Sciences [1020271] Funding Source: National Science Foundation
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0820940, 0820619] Funding Source: National Science Foundation
- Intramural NIH HHS [Z01 HG000024] Funding Source: Medline
- Medical Research Council [G0000934, G0600705] Funding Source: Medline
- NCRR NIH HHS [M01 RR 16500, M01 RR016500] Funding Source: Medline
- NHGRI NIH HHS [R01 HG002651-05S2, R01 HG002651, HG002651, N01HG65403] Funding Source: Medline
- NHLBI NIH HHS [U01 HL084729, U01 HL084729-03, N01-HC-55015, N01-HC-55019, HL72515, N01-HC-55016, N01HC55021, N01-HC-55018, N01HC55019, U01 HL072515, N01HC55016, N01-HC-55020, HL084729, N01HC55015, N01-HC-55021, N01HC55022, N01HC55020, N01-HC-55022, N01HC55018] Funding Source: Medline
- NIAMS NIH HHS [AR046838, R01 AR046838] Funding Source: Medline
- NIA NIH HHS [R01 AG018728, AG18728] Funding Source: Medline
- NIDDK NIH HHS [DK062370, DK54361, R01 DK072193, R01 DK072193-04, DK072193, P30 DK072488, R01 DK062370, R56 DK062370, U01 DK062370, R01 DK029867] Funding Source: Medline
- Wellcome Trust [068545/Z/02] Funding Source: Medline
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Identifying genetic variants that influence human height will advance our understanding of skeletal growth and development. Several rare genetic variants have been convincingly and reproducibly associated with height in mendelian syndromes, and common variants in the transcription factor gene HMGA2 are associated with variation in height in the general population(1). Here we report genome-wide association analyses, using genotyped and imputed markers, of 6,669 individuals from Finland and Sardinia, and follow-up analyses in an additional 28,801 individuals. We show that common variants in the osteoarthritis-associated locus(2) GDF5-UQCC contribute to variation in height with an estimated additive effect of 0.44 cm (overall P < 10(-15)). Our results indicate that there may be a link between the genetic basis of height and osteoarthritis, potentially mediated through alterations in bone growth and development.
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