Journal
NATURE GENETICS
Volume 40, Issue 8, Pages 952-954Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.164
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- Medical Research Council [MC_U120097112, MC_U120061454] Funding Source: Medline
- Medical Research Council [MC_U120061454] Funding Source: researchfish
- MRC [MC_U120061454] Funding Source: UKRI
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To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension.
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