Journal
NATURE GENETICS
Volume 40, Issue 9, Pages 1059-1061Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.200
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Funding
- US National Institutes of Health [AI063274, AR052125, AR043247]
- NIH NSRA award [5F32AR50927-RRG]
- Lupus Foundation of Minnesota
- Arthritis Foundation
- Wellcome Trust [076113]
- ENH/Northwestern University [MH059571]
- Emory University School of Medicine [MH59587]
- Louisiana State University Health Sciences Center, New Orleans, Louisiana [MH067257]
- University of California-Irvine [MH60870]
- Washington University, St. Louis [U01, MH060879]
- University of Iowa, Iowa [MH59566]
- University of Colorado [MH059565]
- University of Pennsylvania [MH061675]
- University of Queensland [MH059588]
- Mt. Sinai School of Medicine [MH59586]
- Massachusetts General Hospital [63420]
- Canadian Institute of Health Research [CIHR 62840]
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Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10-(12), OR = 2.29). We also found evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis ( RA). These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA.
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