Journal
NATURE GENETICS
Volume 40, Issue 11, Pages 1300-1306Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.235
Keywords
-
Categories
Funding
- HHMI
- Human Frontiers Science Program
Ask authors/readers for more resources
Cells regulate gene expression using a complex network of signaling pathways, transcription factors and promoters. To gain insight into the structure and function of these networks, we analyzed gene expression in single- and multiple-mutant strains to build a quantitative model of the Hog1 MAPK-dependent osmotic stress response in budding yeast. Our model reveals that the Hog1 and general stress (Msn2/4) pathways interact, at both the signaling and promoter level, to integrate information and create a context-dependent response. This study lays out a path to identifying and characterizing the role of signal integration and processing in other gene regulatory networks.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available