Journal
NATURE GENETICS
Volume 40, Issue 2, Pages 152-154Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.71
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Funding
- NCRR NIH HHS [RR020143, RR01577, RR14467] Funding Source: Medline
- NHLBI NIH HHS [HL 34363] Funding Source: Medline
- NIAID NIH HHS [AI31584, AI24717, AI044902, AI063622, AI053747] Funding Source: Medline
- NIAMS NIH HHS [P30 AR053483, AR12253, AR049084, AR048940, AR048928, AR42460] Funding Source: Medline
- NIDCR NIH HHS [DE15223] Funding Source: Medline
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We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P 1.7 x 10(-17), odds ratio 1.78). We further replicated this association in two independent samples of individuals of African descent (P = 0.0002 and 0.003; overall meta-analysis P 6.9 x 10(-22)). The genetic association between ITGAM and SLE implicates the alpha(M)beta(2)-integrin adhesion pathway in disease development.
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