Journal
NATURE GENETICS
Volume 40, Issue 12, Pages 1402-1403Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.251
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Funding
- MS Research Netherlands
- Erasmus University Trust Fund
- Netherlands Organisation for Scientific Research
- Erasmus MC
- Multiple Sclerosis Society of Canada Scientific Research Foundation
- Multiple Sclerosis Society of the United Kingdom
- Centre for Medical Systems Biology (CMSB)
- Bibbi and Nils Jensen Foundation
- Swedish Research Council
- EU [LSHM-CT-2005-018637]
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The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.
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