Journal
NATURE GENETICS
Volume 40, Issue 5, Pages 494-495Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng0508-494
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The progression of carcinomas to high- grade malignancies is accompanied by profound histological changes in the tumor-associated stroma. Although previous studies have suggested that mesenchymal cells of the stroma undergo genetic alterations during this progression, a new study now provides evidence that strongly contradicts this theory of stromal cell coevolution.
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