Journal
NATURE GENETICS
Volume 40, Issue 10, Pages 1153-1155Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.214
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Funding
- National Cancer Institute [CA106523, CA95052, CA112517, CA58236, CA86323]
- Department of Defense [PC051264]
- Swedish Cancer Society (Cancerfonden)
- Swedish Research Council
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We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, similar to 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 x 10(-9) for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.
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