Journal
NATURE CHEMISTRY
Volume 6, Issue 6, Pages 511-518Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEM.1937
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Funding
- JST (Japan Science and Technology Agency), the CREST (Core Research for Evolutionary Science and Technology) program
- Scientific Research on the Innovative Areas 'Molecular Robotics' [25104512]
- global Centre of Excellence program, 'Integrated Materials Science' of the Ministry of Education, Culture, Science, Sports and Technology (Japan)
- Tokuyama Science Foundation
- JSPS (Japan Society for the Promotion of Science)
- [23681022]
- Grants-in-Aid for Scientific Research [25104512, 13J05008] Funding Source: KAKEN
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Soft materials that exhibit stimuli-responsive behaviour under aqueous conditions (such as supramolecular hydrogels composed of self-assembled nanofibres) have many potential biological applications. However, designing a macroscopic response to structurally complex biochemical stimuli in these materials still remains a challenge. Here we show that redoxresponsive peptide-based hydrogels have the ability to encapsulate enzymes and still retain their activities. Moreover, cooperative coupling of enzymatic reactions with the gel response enables us to construct unique stimuli-responsive soft materials capable of sensing a variety of disease-related biomarkers. The programmable gel-sol response (even to biological samples) is visible to the naked eye. Furthermore, we built Boolean logic gates (OR and AND) into the hydrogel-enzyme hybrid materials, which were able to sense simultaneously plural specific biochemicals and execute a controlled drug release in accordance with the logic operation. The intelligent soft materials that we have developed may prove valuable in future medical diagnostics or treatments.
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