Journal
NATURE CHEMISTRY
Volume 3, Issue 6, Pages 484-488Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEM.1044
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology, Japan [B01, 2105]
- Grants-in-Aid for Scientific Research [21106010, 21350021] Funding Source: KAKEN
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Cyst nematodes are troublesome parasites that live on, and destroy, a range of important host vegetable plants. Damage caused by the potato cyst nematode has now been reported in over 50 countries. One approach to eliminating the problem is to stimulate early hatching of the nematodes, but key hatching stimuli are not naturally available in sufficient quantities to do so. Here, we report the first chemical synthesis of solanoeclepin A, the key hatch-stimulating substance for potato cyst nematode. The crucial steps in our synthesis are an intramolecular cyclization reaction for construction of the highly strained tricyclo[5.2.1.0(1,6)] decane skeleton (DEF ring system) and an intramolecular Diels-Alder reaction of a furan derivative for the synthesis of the ABC carbon framework. The present synthesis has the potential to contribute to addressing one of the critical food issues of the twenty-first century.
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