Journal
NATURE CHEMICAL BIOLOGY
Volume 14, Issue 9, Pages 841-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41589-018-0101-9
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Funding
- Deutsche Forschungsgemeinschaft [SFB 1127]
- Deutsche Forschungsgemeinschaft (ChemBioSys)
- Deutsche Forschungsgemeinschaft (Leibniz Award)
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Genome mining and chemical analyses revealed that rhizo-sphere bacteria (Paraburkholderia graminis) produce a new type of siderophore, gramibactin, a lipodepsipeptide that efficiently binds iron with a log beta value of 27.6. Complexation-induced proton NMR chemical shifts show that the unusual N-nitrosohydroxylamine (diazeniumdiolate) moieties participate in metal binding. Gramibactin biosynthesis genes are conserved in numerous plant-associated bacteria associated with rice, wheat, and maize, which may utilize iron from the complex.
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