Journal
NATURE CHEMICAL BIOLOGY
Volume 10, Issue 4, Pages 248-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.1459
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Funding
- US National Institutes of Health [HL094463, GM102137, HL62244, HL096972, GM38060, HL096679, HL117659]
- US National Institutes of Health Research Training Grant [T32-HL007149]
- Royal Thai Government fellowship
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Low-molecular-weight heparins (LMWHs) are carbohydrate-based anticoagulants clinically used to treat thrombotic disorders, but impurities, structural heterogeneity or functional irreversibility can limit treatment options. We report a series of synthetic LMWHs prepared by cost-effective chemoenzymatic methods. The high activity of one defined synthetic LMWH against human factor Xa (FXa) was reversible in vitro and in vivo using protamine, demonstrating that synthetically accessible constructs can have a critical role in the next generation of LMWHs.
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