Journal
NATURE CHEMICAL BIOLOGY
Volume 10, Issue 7, Pages 552-554Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.1527
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Funding
- US National Institutes of Health [1R01GM085128, 1DP1GM106413]
- Natural Sciences and Engineering Research Council of Canada
- Canada Research Chair in Bioorganic and Medicinal Chemistry
- US National Science Foundation (NSF) [CHE-1059084]
- Chemistry Biology Interface program [T32GM008496]
- NSF [CHE-1048804]
- Extreme Science and Engineering Design Environment program [TG-CHE040013N]
- Direct For Mathematical & Physical Scien [1059084, 1361104] Funding Source: National Science Foundation
- Division Of Chemistry [1059084, 1361104] Funding Source: National Science Foundation
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Despite the remarkable versatility displayed by flavin-dependent monooxygenases (FMOs) in natural product biosynthesis, one notably missing activity is the oxidative generation of carbonate functional groups. We describe a multifunctional Baeyer-Villiger monooxygenase, CcsB, which catalyzes the formation of an in-line carbonate in the macrocyclic portion of cytochalasin E. This study expands the repertoire of activities of FMOs and provides a possible synthetic strategy for transformation of ketones into carbonates.
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