Journal
NATURE CHEMICAL BIOLOGY
Volume 10, Issue 8, Pages 640-U182Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.1564
Keywords
-
Categories
Funding
- US National Science Foundation [OCE-1313747]
- US National Institute of Environmental Health Sciences through the Oceans and Human Health program [P01-ES021921]
- Gordon and Betty Moore Foundation Marine Microbial Sequencing Project
- Helen Hay Whitney Foundation postdoctoral fellowship
- US National Institutes of Health (NIH) Marine Biotechnology Training Grant predoctoral fellowship [T32-GM067550]
- NIH [S10-RR031562]
- Division Of Ocean Sciences
- Directorate For Geosciences [1313747] Funding Source: National Science Foundation
Ask authors/readers for more resources
Polybrominated diphenyl ethers (PBDEs) and polybrominated bipyrroles are natural products that bioaccumulate in the marine food chain. PBDEs have attracted widespread attention because of their persistence in the environment and potential toxicity to humans. However, the natural origins of PBDE biosynthesis are not known. Here we report marine bacteria as producers of PBDEs and establish a genetic and molecular foundation for their production that unifies paradigms for the elaboration of bromophenols and bromopyrroles abundant in marine biota. We provide biochemical evidence of marine brominases revealing decarboxylative-halogenation enzymology previously unknown among halogenating enzymes. Biosynthetic motifs discovered in our study were used to mine sequence databases to discover unrealized marine bacterial producers of organobromine compounds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available