Journal
NATURE CHEMICAL BIOLOGY
Volume 9, Issue 3, Pages 157-159Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.1162
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Funding
- US National Institutes of Health [GM58822]
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The enterococcal cytolysin is a two-component lantibiotic of unknown structure with hemolytic activity that is important for virulence. We prepared cytolysin by coexpression of each precursor peptide with the synthetase CylM in Escherichia con and characterized its structure. Unexpectedly, cytolysin is to our knowledge the first example of a lantibiotic containing lanthionine and methyllanthionine structures with different stereochemistries in the same peptide. The stereochemistry is determined by the sequence of the substrate peptide.
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