Journal
NATURE CHEMICAL BIOLOGY
Volume 9, Issue 11, Pages 674-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.1355
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Funding
- Agence Nationale de la Recherche
- UK Medical Research Council [MC_UP_A253_1111]
- European Union [241745]
- Region Midi-Pyrenees (Contrat de Projets Etat-Region Midi-Pyrenees (CPER))
- Grand Toulouse community
- Agence pour la Recherche sur le Cancer (ARC) [8505]
- Centre National de la Recherche Scientifique
- European Union-European Regional Development Fund program
- Fondation pour la Recherche Medicale
- MRC [MC_UP_A253_1111, MR/J006874/1] Funding Source: UKRI
- Medical Research Council [MC_UP_A253_1111] Funding Source: researchfish
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Here we identify the amino acid transporter AnsP1 as the unique aspartate importer in the human pathogen Mycobacterium tuberculosis. Metabolomic analysis of a mutant with an inactive AnsP1 revealed that the transporter is essential for M. tuberculosis to assimilate nitrogen from aspartate. Virulence of the AnsP1 mutant is impaired in vivo, revealing that aspartate is a primary nitrogen source required for host colonization by the tuberculosis bacillus.
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