Journal
NATURE CHEMICAL BIOLOGY
Volume 9, Issue 4, Pages 244-246Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.1178
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Funding
- US National Institutes of Health (NIH) [5R01GM52413]
- Internal Grant Agency of Palacky University [PrF_2012_016]
- Grant Agency of the Academy of Sciences of the Czech Republic [KAN200380801]
- NIH [R01GM6863I]
- National Science Foundation [EEC-0813570, MCB-0645794]
- Howard Hughes Medical Institute
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We identify an Arabidopsis pyridoxal-phosphate-dependent aminotransferase, VAS1, whose loss-of-function simultaneously increases amounts of the phytohormone auxin and the ethylene precursor 1-aminocyclopropane-1-carboxylate. VAS1 uses the ethylene biosynthetic intermediate methionine as an amino donor and the auxin biosynthetic intermediate indole-3-pyruvic acid as an amino acceptor to produce L-tryptophan and 2-oxo-4-methylthiobutyric acid. Our data indicate that VAS1 serves key roles in coordinating the amounts of these two vital hormones.
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