Journal
NATURE CHEMICAL BIOLOGY
Volume 9, Issue 6, Pages 353-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.1231
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Funding
- US National Institutes of Health (NIH) grant [T32 GM068411]
- Hooker fellowship
- NIH [RR026501, GM063162, GM103393, RR001209]
- US Department of Energy
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PreQ(1) riboswitches regulate genes by binding the pyrrolopyrimidine intermediate preQ(1) during the biosynthesis of the essential tRNA base queuosine. We report what is to our knowledge the first preQ(1)-II riboswitch structure at 2.3-angstrom resolution, which uses a previously uncharacterized fold to achieve effector recognition at the confluence of a three-way helical junction flanking a pseudoknotted ribosome-binding site. The results account for translational control mediated by the preQ(1)-II riboswitch class and expand the known repertoire of ligand-binding modes used by regulatory RNAs.
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