Journal
NATURE CHEMICAL BIOLOGY
Volume 9, Issue 3, Pages 160-162Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.1164
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Funding
- Ministry of Education, Culture, Sports, Science and Technology Japan [24227003]
- Japan Society for the Promotion of Science (JSPS) [18077001]
- Astellas Foundation for Research on Metabolic Disorders
- Grants-in-Aid for Scientific Research [18077001, 23102001] Funding Source: KAKEN
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We report the identification of a physiological receptor-volatile pair in the mouse olfactory system. By activity-guided fractionation of exocrine gland extracts and subsequent chemical analysis, (Z)-5-tetradecen-1-ol was identified as a natural ligand for a mouse odorant receptor. (Z)-5-tetradecen-1-ol is excreted into male mouse urine under androgen control and enhances urine attractiveness to female mice. This report is to our knowledge the first to describe natural product-based deorphanization of an odorant receptor.
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