Journal
NATURE CHEMICAL BIOLOGY
Volume 9, Issue 10, Pages 594-598Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.1339
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Funding
- Division of Chemical Sciences, Geosciences and Biosciences, Office of Basic Energy Sciences of the US Department of Energy [DE-FG02-98ER20311]
- National Institute of General Medical Sciences [GM22854]
- DARPA [N66001-12-C-4020, N66001-12-C-4211]
- National Science Foundation [MCB-0950474]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0950474] Funding Source: National Science Foundation
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Genetic code expansion for synthesis of proteins containing noncanonical amino acids is a rapidly growing field in synthetic biology. Creating optimal orthogonal translation systems will require re-engineering central components of the protein synthesis machinery on the basis of a solid mechanistic biochemical understanding of the synthetic process.
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