4.8 Review

Engineering synthetic recursive pathways to generate non-natural small molecules

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

Engineering of Bacterial Methyl Ketone Synthesis for Biofuels

Ee-Been Goh et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2012)

Article Chemistry, Multidisciplinary

Modular Pathway Engineering of Diterpenoid Synthases and the Mevalonic Acid Pathway for Miltiradiene Production

Yongjin J. Zhou et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Multidisciplinary Sciences

Modularity of a carbon-fixing protein organelle

Walter Bonacci et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Chemistry, Multidisciplinary

Engineering of an Unnatural Natural Product by Swapping Polyketide Synthase Domains in Aspergillus nidulans

Ting Liu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Multidisciplinary Sciences

Engineered reversal of the β-oxidation cycle for the synthesis of fuels and chemicals

Clementina Dellomonaco et al.

NATURE (2011)

Article Biotechnology & Applied Microbiology

Optimization of a heterologous pathway for the production of flavonoids from glucose

Christine Nicole S. Santos et al.

METABOLIC ENGINEERING (2011)

Review Chemistry, Applied

Metabolic Engineering for the Production of Natural Products

Lauren B. Pickens et al.

ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING, VOL 2 (2011)

Review Chemistry, Multidisciplinary

Advances in Quantum and Molecular Mechanical (QM/MM) Simulations for Organic and Enzymatic Reactions

Orlando Acevedo et al.

ACCOUNTS OF CHEMICAL RESEARCH (2010)

Article Biotechnology & Applied Microbiology

A Process for Microbial Hydrocarbon Synthesis: Overproduction of Fatty Acids in Escherichia coli and Catalytic Conversion to Alkanes

Rebecca M. Lennen et al.

BIOTECHNOLOGY AND BIOENGINEERING (2010)

Review Plant Sciences

Tailoring plant lipid composition: designer oilseeds come of age

Johnathan A. Napier et al.

CURRENT OPINION IN PLANT BIOLOGY (2010)

Article Chemistry, Multidisciplinary

Mechanism and Engineering of Polyketide Chain Initiation in Fredericamycin Biosynthesis

Abhirup Das et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Chemistry, Multidisciplinary

Exploiting Enzymatic Promiscuity to Engineer a Focused Library of Highly Selective Antifungal and Antiproliferative Aureothin Analogues

Martina Werneburg et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Multidisciplinary Sciences

Microbial production of fatty-acid-derived fuels and chemicals from plant biomass

Eric J. Steen et al.

NATURE (2010)

Review Chemistry, Multidisciplinary

Organocatalytic cascade reactions as a new tool in total synthesis

Christoph Grondal et al.

NATURE CHEMISTRY (2010)

Review Microbiology

New insights into the formation of fungal aromatic polyketides

Jason M. Crawford et al.

NATURE REVIEWS MICROBIOLOGY (2010)

Article Multidisciplinary Sciences

Short N-terminal sequences package proteins into bacterial microcompartments

Chenguang Fan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

Evaluation and ranking of enzyme designs

Gert Kiss et al.

PROTEIN SCIENCE (2010)

Article Multidisciplinary Sciences

Structure and Mechanisms of a Protein-Based Organelle in Escherichia coli

Shiho Tanaka et al.

SCIENCE (2010)

Article Multidisciplinary Sciences

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

Parayil Kumaran Ajikumar et al.

SCIENCE (2010)

Review Plant Sciences

Biosynthesis of glucosinolates - gene discovery and beyond

Ida E. Sonderby et al.

TRENDS IN PLANT SCIENCE (2010)

Article Biochemistry & Molecular Biology

Mapping the Limits of Substrate Specificity of the Adenylation Domain of TycA

Benoit R. M. Villiers et al.

CHEMBIOCHEM (2009)

Review Biochemistry & Molecular Biology

Directed enzyme evolution: climbing fitness peaks one amino acid at a time

Cara A. Tracewell et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2009)

Article Chemistry, Multidisciplinary

A Novel Method for Enzyme Design

Xiaolei Zhu et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)

Article Chemistry, Multidisciplinary

Nucleobase-Templated Polymerization: Copying the Chain Length and Polydispersity of Living Polymers into Conjugated Polymers

Pik Kwan Lo et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Biotechnology & Applied Microbiology

Synthetic protein scaffolds provide modular control over metabolic flux

John E. Dueber et al.

NATURE BIOTECHNOLOGY (2009)

Article Biotechnology & Applied Microbiology

Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering

Wenjuan Zha et al.

METABOLIC ENGINEERING (2009)

Article Biochemistry & Molecular Biology

MODBASE, a database of annotated comparative protein structure models and associated resources

Ursula Pieper et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Plant Sciences

Methylthioalkylmalate synthases: genetics, ecology and evolution

Markus Benderoth et al.

PHYTOCHEMISTRY REVIEWS (2009)

Article Biochemistry & Molecular Biology

Covalent linkage mediates communication between ACP and TE domains in modular polyketide synthases

Lucky Tran et al.

CHEMBIOCHEM (2008)

Review Biochemistry & Molecular Biology

Unearthing the roots of the terpenome

David W. Christianson

CURRENT OPINION IN CHEMICAL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Methanogen Homoaconitase Catalyzes Both Hydrolyase Reactions in Coenzyme B Biosynthesis

Randy M. Drevland et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Chemistry, Multidisciplinary

Redirecting the cyclization steps of fungal polyketide synthase

Suzanne M. Ma et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Review Medicine, Research & Experimental

Nonribosomal peptide synthetases involved in the production of medically relevant natural products

Elizabeth A. Felnagle et al.

MOLECULAR PHARMACEUTICS (2008)

Article Multidisciplinary Sciences

Kemp elimination catalysts by computational enzyme design

Daniela Rothlisberger et al.

NATURE (2008)

Article Multidisciplinary Sciences

Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels

Shota Atsumi et al.

NATURE (2008)

Article Biochemistry & Molecular Biology

Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases

Paul E. O'Maille et al.

NATURE CHEMICAL BIOLOGY (2008)

Article Biotechnology & Applied Microbiology

Metabolic engineering of Escherichia coli for 1-butanol and 1-propanol production via the keto-acid pathways

C. R. Shen et al.

METABOLIC ENGINEERING (2008)

Article Biotechnology & Applied Microbiology

Overproduction of free fatty acids in E. coli: Implications for biodiesel production

Xuefeng Lu et al.

METABOLIC ENGINEERING (2008)

Article Multidisciplinary Sciences

Expanding metabolism for biosynthesis of nonnatural alcohols

Kechun Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

De novo computational design of retro-aldol enzymes

Lin Jiang et al.

SCIENCE (2008)

Article Biochemical Research Methods

The origins of specificity in polyketide synthase protein interactions

Mukund Thattai et al.

PLOS COMPUTATIONAL BIOLOGY (2007)

Article Biotechnology & Applied Microbiology

Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli

Effendi Leonard et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)

Article Evolutionary Biology

Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution

Christian Rausch et al.

BMC EVOLUTIONARY BIOLOGY (2007)

Article Multidisciplinary Sciences

Chimeras of two isoprenoid synthases catalyze all four coupling reactions in isoprenoid biosynthesis

Hirekodathakallu V. Thulasiram et al.

SCIENCE (2007)

Article Biotechnology & Applied Microbiology

Mutasynthesis - uniting chemistry and genetics for drug discovery

Kira J. Weissman

TRENDS IN BIOTECHNOLOGY (2007)

Article Multidisciplinary Sciences

Total synthesis of marine natural products without using protecting groups

Phil S. Baran et al.

NATURE (2007)

Review Biotechnology & Applied Microbiology

Biosynthesis and engineering of isoprenoid small molecules

Sydnor T. Withers et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2007)

Article Multidisciplinary Sciences

Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases

Bryan T. Greenhagen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Positive selection driving diversification in plant secondary metabolism

Markus Benderoth et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Biotechnology & Applied Microbiology

Polyhedral organelles compartmenting bacterial metabolic processes

TA Bobik

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2006)

Article Multidisciplinary Sciences

Harnessing the potential of communication-mediating domains for the biocombinatorial synthesis of nonribosomal peptides

M Hahn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Engineering cotton (+)-delta-cadinene synthase to an altered function: Germacrene D-4-ol synthase

Y Yoshikuni et al.

CHEMISTRY & BIOLOGY (2006)

Review Biochemistry & Molecular Biology

C-C bond formation and cleavage in radical enzymes, a theoretical perspective

F Himo

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2005)

Article Multidisciplinary Sciences

Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis

N Koon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Biochemistry & Molecular Biology

Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity

SJ Moss et al.

NATURAL PRODUCT REPORTS (2004)

Article Multidisciplinary Sciences

Design of a novel globular protein fold with atomic-level accuracy

B Kuhlman et al.

SCIENCE (2003)

Article Multidisciplinary Sciences

Computational design of receptor and sensor proteins with novel functions

LL Looger et al.

NATURE (2003)

Review Biochemistry & Molecular Biology

The chalcone synthase superfamily of type III polyketide synthases

MB Austin et al.

NATURAL PRODUCT REPORTS (2003)

Review Chemistry, Multidisciplinary

Catalytic chain transfer in free-radical polymerizations

AA Gridnev et al.

CHEMICAL REVIEWS (2001)

Article Plant Sciences

Genetic control of natural variation in Arabidopsis glucosinolate accumulation

DJ Kliebenstein et al.

PLANT PHYSIOLOGY (2001)

Article Biotechnology & Applied Microbiology

The effects of feed and intracellular pyruvate levels on the redistribution of metabolic fluxes in Escherichia coli

YT Yang et al.

METABOLIC ENGINEERING (2001)

Review Multidisciplinary Sciences

Modular enzymes

C Khosla et al.

NATURE (2001)