Journal
NATURE CHEMICAL BIOLOGY
Volume 8, Issue 9, Pages 748-750Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.1043
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Funding
- UK Medical Research Council (MRC) [U105181009, UD99999908]
- Louis-Jeantet Foundation Young Investigator Career Award
- MRC [MC_UP_A024_1008] Funding Source: UKRI
- Medical Research Council [MC_UP_A024_1008] Funding Source: researchfish
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Genetic code expansion for unnatural amino acid mutagenesis has, until recently, been limited to cell culture. We demonstrate the site-specific incorporation of unnatural amino acids into proteins in Drosophila melanogaster at different developmental stages, in specific tissues and in a subset of cells within a tissue. This approach provides a foundation for probing and controlling processes in this established metazoan model organism with a new level of molecular precision.
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