Journal
NATURE CHEMICAL BIOLOGY
Volume 8, Issue 8, Pages 674-677Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.1024
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Defining G protein-coupled receptor ligand efficacy and biased agonism in precise chemical terms is one challenge posed by the current structural data that exists for this receptor family. Concepts classically used for understanding enzymes and other nonreceptor proteins may lead us in the right direction.
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