Journal
NATURE CHEMICAL BIOLOGY
Volume 7, Issue 7, Pages 425-427Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.577
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Funding
- Australian Research Council
- National Health and Medical Research Council
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The design of proteins that can bind any RNA sequence of interest has many potential biological and medical applications. Here we have expanded the recognition of Pumilio and FBF homology protein (PUF) repeats beyond adenine, guanine and uracil and evolved them to specifically bind cytosine. These repeat sequences can be used to create PUF domains capable of selectively binding RNA targets of diverse sequence and structure.
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