Journal
NATURE CHEMICAL BIOLOGY
Volume 7, Issue 5, Pages 257-259Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.542
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Funding
- United States Department of Agriculture Initiative for Future Agriculture and Food Systems
- National Science Foundation
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The cyclic peptide sunflower trypsin inhibitor 1 (SFTI-1) blocks trypsin and is a promising drug lead and protein engineering scaffold. We show that SFTI-1 and the newfound SFT-L1 are buried within PawS1 and PawS2, precursors for seed storage protein albumins. Proalbumins are matured by asparaginyl endopeptidase, which we show is required to liberate both ends of SFTI-1 as well as to mature PawS1 albumin. Thus, these peptides emerge from within an albumin precursor by the action of albumin's own processing enzyme.
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