Journal
NATURE CHEMICAL BIOLOGY
Volume 7, Issue 11, Pages 766-768Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.667
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Funding
- European Molecular Biology Organization
- International Human Frontier Science Program Organization
- Marc and Eva Stern foundation
- US National Institutes of Health (NIH) [5R01GM52413]
- US National Science Foundation [IOS-0649389]
- Howard Hughes Medical Institute
- NIH [P30 NS057096]
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Cytokinins are classic hormones that orchestrate plant growth and development and the integrity of stem cell populations. Cytokinin receptors are eukaryotic sensor histidine kinases that are activated by both naturally occurring adenine-type cytokinins and urea-based synthetic compounds. Crystal structures of the Arabidopsis thaliana histidine kinase 4 sensor domain in complex with different cytokinin ligands now rationalize the hormone-binding specificity of the receptor and may spur the design of new cytokinin ligands.
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