Journal
NATURE CHEMICAL BIOLOGY
Volume 7, Issue 6, Pages 348-350Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.559
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Funding
- Canada Research Chairs
- Canadian Cystic Fibrosis Foundation
- Canadian Institutes of Health Research [MOP-81330, XNE-8705, FRN-79488]
- European Research Council
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Combinations of antibiotics are commonly used in medicine to broaden antimicrobial spectrum and generate synergistic effects. Alternatively, combination of nonantibiotic drugs with antibiotics offers an opportunity to sample a previously untapped expanse of bioactive chemical space. We screened a collection of drugs to identify compounds that augment the activity of the antibiotic minocycline. Unexpected synergistic drug combinations exhibited in vitro and in vivo activity against bacterial pathogens, including multidrug-resistant isolates.
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