Journal
NATURE CHEMICAL BIOLOGY
Volume 8, Issue 2, Pages 141-143Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.761
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Funding
- German Federal Ministry for Education [BMBF 01GS08104]
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Until now, a lack of inhibitors with high potency and selectivity in vivo has hampered investigation of the p38 mitogen-activated protein kinase (MAPK) signaling pathway. We describe the design of skepinone-L, which is, to our knowledge, the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy and selectivity. Therefore, skepinone-L is a valuable probe for chemical biology research, and it may foster the development of a unique class of kinase inhibitors.
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