Journal
NATURE CHEMICAL BIOLOGY
Volume 6, Issue 4, Pages 261-263Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.331
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Funding
- Max Planck Society
- German Research Foundation Deutsche Forschungsgemeinschaft
- Volkswagen Foundation
- International Leibniz Research School for Microbial and Biomolecular Interactions
- Jena School for Microbial Communication
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Beewolf digger wasps cultivate specific symbiotic bacteria (Streptomyces spp.) that are incorporated into the larval cocoon for protection against pathogens. We identified the molecular basis of this protective symbiosis in the natural context and demonstrate that the bacteria produce a 'cocktail' of nine antibiotic substances. The complementary action of all symbiont-produced antibiotics confers a potent antimicrobial defense for the wasp larvae that parallels the 'combination prophylaxis' known from human medicine.
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