Journal
NATURE CHEMICAL BIOLOGY
Volume 6, Issue 6, Pages 464-470Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.369
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Funding
- US National Institutes of Health [GM074070]
- Arnold and Mabel Beckman Foundation
- American Chemical Society
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM074070] Funding Source: NIH RePORTER
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A major goal of synthetic biology is to reprogram cells to perform complex tasks. Here we show how a combination of in vitro and in vivo selection rapidly identifies a synthetic riboswitch that activates protein translation in response to the herbicide atrazine. We further demonstrate that this riboswitch can reprogram bacteria to migrate in the presence of atrazine. Finally, we show that incorporating a gene from an atrazine catabolic pathway allows these cells to seek and destroy atrazine.
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