Journal
NATURE CHEMICAL BIOLOGY
Volume 6, Issue 4, Pages 258-260Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.333
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Funding
- US National Heart, Lung, and Blood Institute [NO1 HV28185]
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Advances in high-throughput screening now enable the rapid discovery of bioactive small molecules, but these primary hits almost always exhibit modest potency. We report a strategy for the transformation of these hits into much more potent inhibitors without compound optimization. Appending a derivative of Ru(II)(tris-bipyridyl)(2+), an efficient photosensitizer of singlet oxygen production, to synthetic protein-binding compounds results in highly potent and specific target protein inactivation upon irradiation with visible light.
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