Journal
NATURE CHEMICAL BIOLOGY
Volume 5, Issue 9, Pages 625-627Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.189
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Funding
- US National Science Foundation [MCB0235705, MCB0640616]
- US National Institutes of Health [AI49174, AI072133, GM061223-05A, GM35394]
- The University of East Anglia
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Glutathione is a nearly ubiquitous, low-molecular-mass thiol and antioxidant, but it is conspicuously absent from most Gram-positive bacteria. We identify here the structure of bacillithiol, a newly described and abundant thiol produced by Bacillus species, Staphylococcus aureus and Deinococcus radiodurans. Bacillithiol is the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid and most probably functions as an antioxidant. Bacillithiol, like the structurally similar mycothiol, may serve as a substitute for glutathione.
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