Journal
NATURE CHEMICAL BIOLOGY
Volume 5, Issue 8, Pages 526-529Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio0809-526
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Protein improvement strategies today involve widely varying combinations of rational design with random mutagenesis and screening. To make further progress-defined as making subsequent protein engineering problems easier to solve-protein engineers must critically compare these strategies and eliminate less effective ones.
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