Journal
NATURE CHEMICAL BIOLOGY
Volume 5, Issue 6, Pages 383-390Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.181
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Funding
- European Union
- Deutsche Forschungsgemeinschaft (DFG)
- Bundesministerium fur Bildung und Forschung (BmbF)
- National Foundation for Scientific Research (FNRS)
- Universite catholique de Louvain
- Region wallonne
- Federal Office for Scientific, Technical and Cultural Affairs
- Communaute fran aise de Belgique
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Biological processes rely on molecular interactions that can be directly measured using force spectroscopy techniques. Here we review how atomic force microscopy can be applied to force probe surfaces of living cells to single-molecule resolution. Such probing of individual interactions can be used to map cell surface receptors, and to assay the receptors' functional states, binding kinetics and landscapes. This information provides unique insight into how cells structurally and functionally modulate the molecules of their surfaces to interact with the cellular environment.
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