Journal
NATURE CHEMICAL BIOLOGY
Volume 5, Issue 10, Pages 721-723Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.212
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Funding
- US National Institutes of Health [DK64959, NIH5P60 DK20572]
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We demonstrate that the mechanism of redox remodeling during mouse T-cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation results in a lower redox potential, which is conducive to proliferation, and changes the net redox status of exofacial protein domains. Regulatory T cells inhibit this redox metabolite signaling pathway, which represents a previously unrecognized mechanism for immunosuppression of effector T cells.
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