Journal
NATURE CHEMICAL BIOLOGY
Volume 6, Issue 2, Pages 102-104Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.282
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Funding
- US National Institutes of Health [RO1 GM069454]
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Small molecules can control cell fate in vivo and may allow directed induction of desired cell types, providing an attractive alternative to transplant-based approaches in regenerative medicine. We have chemically induced functional oocytes in Caenorhabditis elegans adults that otherwise produced only sperm. These findings suggest that chemical approaches to therapeutic cell reprogramming may be feasible and provide a powerful platform for analyzing molecular mechanisms of in vivo cell reprogramming.
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