Journal
NATURE CHEMICAL BIOLOGY
Volume 5, Issue 3, Pages 151-153Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.141
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Funding
- NIGMS NIH HHS [R01 GM074820, R01 GM074820-01A2] Funding Source: Medline
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We transformed an alkaloid biosynthetic gene with reengineered substrate specificity into Catharanthus roseus. The resulting transgenic plant cell culture produced a variety of unnatural alkaloid compounds when cocultured with simple, achiral, commercially available precursors that the reengineered enzyme was designed to accept. This work demonstrates the power of genetic engineering to retailor the structures of complex alkaloid natural products in plant culture.
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